Angiotensin-(1-7)and tumors / 国际肿瘤学杂志

Angiotensin-(1-7)[Ang-(1-7)]is an endogenous peptide-hormone of the renin-angioten-sin system. Ang-(1-7),angiotensin-converting enzyme 2( ACE2)and MAS receptor constitute ACE2-Ang-(1-7)-Mas axis,which antagonizes the ACE-AngⅡ-AngⅡ type 1 receptor axis. Recent studies indicate that Ang-(1-7)has certain effects on treating tumors,including inhibition of angiogenesis,anti-cell proliferation and inhibition of tumor fibrosis. Researches on the roles and mechanisms of Ang-(1-7)can provide new target for treatment and prevention of cancer.